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. 1998 Dec 8;95(25):14833–14838. doi: 10.1073/pnas.95.25.14833

Figure 5.

Figure 5

MKP-1 does not prevent neurectoderm-specific gene expression in noggin-overexpressing ectoderm. Animal caps were isolated at stage 8 from embryos coinjected with 100 pg of noggin plus 4 ng of MKP-1 or ΔP-MKP mRNA. Half of them were assayed for MAPK activity when controls reached stage 11, and half of them were used for RT-PCR assays when controls reached stage 13. (A) Overexpression of MKP-1 decreases MAPK activity in expressing noggin-injected animal cap ectoderm. (B) Expression of NCAM and otx2 is not affected by MKP-1 (n = 6).