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. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: Exp Neurol. 2008 Mar 2;211(2):469–479. doi: 10.1016/j.expneurol.2008.02.011

Fig. 2. Paw skin biopsy for nerve fibers.

Fig. 2

Images show sections immunostained with anti-PGP 9.5 antibody in 50 µm cryosections from the hind limb. The arrow indicates intraepidermal nerve fibers; arrow heads indicate dermal nerve fibers (scale bar 30 µm). There is a marked reduction in IENFD in the diabetic rats (B) as compared with the non-diabetic control (A). Lower panel (C) indicates the measurement of IENFD both in non-diabetic and diabetic animals. **P<0.001 as compared to non-diabetic control animals.