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. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: Clin Perinatol. 2008 Jun;35(2):373–vii. doi: 10.1016/j.clp.2008.03.006

Figure 4. A schematic model for assembly and regulation of amiloride-sensitive sodium channels in the lung. Alveolar environment, particularly oxygen tension, steroid exposure, and alveolar distension, are likely to influence assembly of ENaC subunits. Signal transduction pathways mediated by several protein kinases including A, G, and C regulate each of these channel types in different ways. T1 and T2 cells with different channel types (and, therefore, different regulation) will have very different levels of sodium transport that will respond quite differently to hormonal and transmitter agents.

Figure 4

From Jain L, Eaton DC: Physiology of fetal lung fluid clearance and the effect of labor. Semin Perinatol 30:37, 2006 with permission