. 2008 May 29;9:255. doi: 10.1186/1471-2164-9-255

Table 2.

Differentially expressed genes common to Leishmania infantum and Leishmania major.

GO annotation (molecular function)	Accession number (GeneDB) L. infantum	Fold increase	Accession number (GeneDB L. major	Fold increase
Metabolic process

3-ketoacyl-coa thiolase	LinJ23_V3.0860	2,1 ^a	LmjF23.0690	3,3 ^a
hydrolase, alpha/beta fold family	LinJ17_V3.1110	1,7 ^a	LmjF17.1010	1,8 ^a
vacuolar ATP synthase subunit B	LinJ28_V3.2610	1,8 ^a	LmjF28.2430	1,7 ^a
succinyl-coA:3-ketoacid-coenzyme A transferase ^b	LinJ33_V3.2470	1,8 ^c	LmjF33.2340	2,1 ^a
hydrolase, alpha/beta fold family	LinJ17_V3.1110	1,7 ^c	LmjF17.1010	1,8 ^c

Carbohydrate metabolic process

acetyl-CoA synthetase	LinJ23_V3.0880	2,0 ^a	LmjF23.0710	4,5 ^a
aldose 1-epimerase	LinJ35_V3.1000	1,8 ^a	LmjF35.0980	2,4 ^a
enolase	LinJ14_V3.1240	2,3 ^a	LmjF14.1160	2,4 ^a
myo-inositol-1-phosphate synthetase	LinJ14_V3.1450	2,4 ^c	LmjF14.1360	4,7 ^c

Lipid metabolic process

3-oxo-5-alpha-steroid 4-dehydrogenase	LinJ25_V3.1850	1,7 ^a	LmjF25.1770	3,0 ^a
fatty acid elongase	LinJ14_V3.0700	2,0 ^a	LmjF14.0670	3,2 ^a
lathosterol oxidase	LinJ23_V3.1560	1,9 ^a	LmjF23.1300	3,6 ^a
phosphoglycan beta 1,3 galactosyltransferase	LinJ02_V3.0140	1,8 ^a	LmjF02.0160	3,8 ^a
phosphoglycan beta 1,3 galactosyltransferase ^d		22,0 ^c		2,4-11,8 ^c
hypothetical	LinJ13_V3.0200	2,7 ^c	LmjF13.0200	3,8 ^c

Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

adenylosuccinate synthetase	LinJ13_V3.1090	1,8 ^a	LmjF13.1190	2,0 ^a
	LinJ25_V3.1210
	LinJ25_V3.2580		LmjF25.1170,
ATPase beta subunit	LinJ25_V3.2590	2,1 ^a	LmjF25.1180	1,9 ^a

DNA metabolic process

3'-nucleotidase/nuclease	LinJ12_V3.0350	2,0 ^a	LmjF12.0400	3,9 ^a
3'-nucleotidase/nuclease precursor	LinJ31_V3.2380	1,7 ^a	LmjF31.2310	4,6 ^a
histone 1	LinJ33_V3.3390	2,6 a	LmjF33.3240	1,9 ^a
3'-nucleotidase/nuclease	LinJ31_V3.2370	2,0 ^c	LmjF31.2300	1,7 ^c
double-strand-break repair protein rad21	LinJ05_V3.1090	3,0 ^c	LmjF05.1090	1,9 ^c

RNA metabolic process

exosome complex exonuclease RRP45	LinJ22_V3.1430	3,1 ^c	LmjF22.1580	1,8 ^c
RNA-binding protein 5	LinJ09_V3.0080	3,4 c	LmjF09.0060	1,7 ^c

Amino acid and derivative metabolic process

glutamate dehydrogenase	LinJ15_V3.1070	1,8 ^a	LmjF15.1010	1,8 ^a

Protein metabolic process

HSP 70	LinJ32_V3.2050	2,0 ^a	LmjF32.1940	1,9 ^a

Proteolysis

	LinJ14_V3.0910,
calpain-like cysteine peptidase	LinJ14_V3.0920	1,7 ^a	LmjF14.0850	4,5 ^a
calpain-like cysteine peptidase	LinJ20_V3.1320	2,0 ^a	LmjF20.1280	2,1 ^a
calpain-like cysteine peptidase	LinJ20_V3.1350	1,7 ^a	LmjF20.1310	2,9 ^a
calpain-like cysteine peptidase	LinJ27_V3.2490	1,8 ^a	LmjF27.0510	2,8 ^a
calpain-like cysteine peptidase	LinJ32_V3.1020	1,8 ^a	LmjF32.0970	1,9 ^a
			LmjF01.0830,
			LmjF02.0740,
peptidyl-dipeptidase	LinJ02_V3.0710	1,7 ^a	LmjF27.2660	2,5 ^a
puromycin-sensitive aminopeptidase-like	LinJ12_V3.0830	2,1 ^c	LmjF12.1250	1,8 ^c

Protein modification process

protein kinase A catalytic subunit	LinJ18_V3.1090	1,9 ^a	LmjF18.1080	3,2 ^a
protein kinase A regulatory subunit	LinJ13_V3.0160	2,5 ^a	LmjF13.0160	2,1 ^a
protein kinase	LinJ30_V3.1780	2,5 ^c	LmjF30.1780	1,7 ^c

Electron transport

trypanothione synthetase	LinJ23_V3.0500	1,7 ^c	LmjF23.0460	1,8 ^c

Cellular component organization and biogenesis

dynein heavy chain	LinJ13_V3.1390	1,7 ^a	LmjF13.1650	2,1 ^a
dynein heavy chain	LinJ26_V3.1000	1,9 ^a	LmjF26.1020	1,7 ^a
dynein heavy chain	LinJ28_V3.0650	1,8 ^a	LmjF28.0610	2,0 ^a
dynein heavy chain (pseudogene)	LinJ27_V3.2460	2,1 ^a	LmjF27.2590	2,0 ^a
dynein light chain	LinJ24_V3.1050	2,0 ^a	LmjF24.1030	2,0 ^a
dynein-associated roadblock	LinJ35_V3.1740	1,8 ^a	LmjF35.1750	2,1 ^a
OSM3-like kinesin	LinJ17_V3.0890	1,7 ^a	LmjF17.0800	2,0 ^a

Cell motility

			LmjF39.1750,
	LinJ29_V3.1880,		LmjF29.1760
PFR 1D	LinJ29_V3.1890	3,9 ^a	LmjF29.1770	4,5 a
	LinJ16_V3.1510,		LmjF16.1425,
PFR 2C	LinJ16_V3.1520	3,7 ^a	LmjF16.1430	5,3 ^a
paraflagellar rod component	LinJ09_V3.1390	1,9 ^a	LmjF09.1320	2,8 ^a

Cell communication

			LmjF09.0910,
	LinJ09_V3.0970,		LmjF09.0920
calmodulin	LinJ09_V3.0980	2,0 ^a	LmjF09.0930	2,8 ^a
calmodulin	LinJ13_V3.1060	1,8 ^a	LmjF13.1160	1,8 ^a
receptor-type adenylate cyclase a	LinJ17_V3.0120	1,7 ^a	LmjF17.0200	1,8 ^a
			LmjF17.0230,
	LinJ17_V3.0140,		LmjF17.0235
receptor-type adenylate cyclase b	LinJ17_V3.0160	1,8 ^a	LmjF17.0237	2,6 ^a

Transport

amino acid transporter aATP11 b	LinJ31_V3.0370	2,4 ^c	LmjF31.0350	4,7 ^a
phosphate-repressible phosphate permease	LinJ03_V3.0480	1,7 ^c	LmjF03.0500	2,0 ^c

Unclassified

oxidoreductase	LinJ36_V3.4380	1,7 ^a	LmjF36.4170	1,7 ^a
leucine rich repeat protein	LinJ32_V3.3200	1,7 ^a	LmjF32.3010	2,2 ^a
leucine rich repeat protein	LinJ10_V3.0160	2,1 ^a	LmjF10.0180	2,3 ^a
protein tyrosine phosphatase	LinJ05_V3.0280	1,8 ^a	LmjF05.0280	2,6 ^a
hypothetical	LinJ01_V3.0640	2,4 ^a	LmjF01.0620	2,3 ^a
hypothetical	LinJ02_V3.0520	3,9 ^a	LmjF02.0550	5,0 ^a
hypothetical	LinJ07_V3.0040	2,0 ^a	LmjF07.0030	1,8 ^a
hypothetical	LinJ07_V3.0470	1,8 ^a	LmjF07.0310	2,7 ^a
hypothetical	LinJ09_V3.1620	2,1 ^a	LmjF09.1530	1,8 ^a
hypothetical	LinJ10_V3.1370	1,9 ^a	LmjF10.1230	1,9 ^a
hypothetical	LinJ11_V3.0620	2,0 ^a	LmjF11.0610	2,1 ^a
hypothetical	LinJ11_V3.1040	2,1 ^a	LmjF11.1040	2,0 ^a
hypothetical	LinJ17_V3.0970	2,0 ^a	LmjF17.0870	3,6 ^a
hypothetical	LinJ18_V3.1640	3,5 ^a	LmjF18.1640	6,6 ^a
hypothetical	LinJ19_V3.0520	4,5 ^a	LmjF19.0520	5,9 ^a
hypothetical	LinJ20_V3.0760	1,7 ^a	LmjF20.0700	1,8 ^a
hypothetical	LinJ21_V3.0440	1,8 ^a	LmjF21.0380	2,5 ^a
hypothetical	LinJ23_V3.1190	2,0 ^a	LmjF23.1020	4,6 a
hypothetical	LinJ24_V3.1630	4,1 ^a	LmjF24.1560	4,1 ^a
hypothetical	LinJ24_V3.2200	2,4 ^a	LmjF24.2110	1,8 ^a
hypothetical	LinJ26_V3.2400	2,1 ^a	Lm jF26.2380	3,0 ^a
hypothetical	LinJ27_V3.0720	1,9 ^a	LmjF27.0870	1,7 ^a
hypothetical	LinJ28_V3.1150	2,1 a	LmjF28.1060	2,9 ^a
hypothetical	LinJ29_V3.0360	1,7 ^a	Lm jF29.0350	1,9 ^a
hypothetical	LinJ29_V3.1090	2,4 ^a	Lm jF29.1000	3,0 ^a
hypothetical	LinJ29_V3.1190	2,0 ^a	Lm jF29.1100	1,8 ^a
hypothetical	LinJ29_V3.1260	2,5 ^a	Lm jF29.1170	3,2 ^a
hypothetical	LinJ29_V3.2940	2,5 ^a	Lm jF29.2830	3,7 ^a
hypothetical	LinJ30_V3.2870	4,4 ^a	Lm jF30.2850	8,5 ^a
hypothetical	LinJ31_V3.1220	2,7 ^a	LmjF31.1200	2,0 ^a
hypothetical	LinJ32_V3.0360	1,7 ^a	Lm jF32.0350	2,0 ^a
hypothetical	LinJ32_V3.0370	2,2 ^a	Lm jF32.0360	2,2 ^a
hypothetical	LinJ32_V3.1840	2,2 ^a	Lm jF32.1760	3,0 ^a
hypothetical	LinJ32_V3.2020	2,8 ^a	Lm jF32.1910	2,4 ^a
hypothetical	LinJ33_V3.0660	3,7 ^a	Lm jF33.0610	5,4 a
hypothetical	LinJ34_V3.1620	2,0 ^a	Lm jF34.1520	4,0 ^a
hypothetical	LinJ34_V3.2590	1,7 ^a	LmjF34.2760	1,8 ^a
hypothetical	LinJ34_V3.4230	1,9 ^a	Lm jF34.4600	3,0 ^a
hypothetical	LinJ35_V3.5310	2,4 ^a	Lm jF35.5340	4,0 ^a
hypothetical	LinJ36_V3.0800	2,4 ^a	LmjF36.0740	1,8 ^a
hypothetical	LinJ36_V3.3000	1,8 ^a	Lm jF36.2850	2,0 ^a
hypothetical	LinJ36_V3.3780	1,8 ^a	Lm jF36.3620	6,7 a
hypothetical	LinJ36_V3.4440	4,1 ^a	Lm jF36.4230	5,7 ^a
hypothetical	LinJ36_V3.5010	2,7 ^a	Lm jF36.4780	3,2 ^a
hypothetical	LinJ36_V3.5140	2,3 a	LmjF36.4910	1,9 ^a
hypothetical	LinJ36_V3.5210	1,8 ^a	LmjF36.4980	2,5 ^a
hypothetical	LinJ35_V3.3780	1,8 ^c	LmjF35.3730	1,7 ^a
			LmjF 23.1050,
	LinJ23_V3.1210,		LmjF 23.1080,
SHERP ^b	LinJ23_V3.1230	2,5 ^c	LmjF23.1086	1,7 ^a
Amastins ^e		1.9–6.8 ^c		1.9–25.4 ^c
			LmjF 05.1230,
			LmjF19.1650
GIPL galf transferase	LinJ32_V3.4140	2,8 ^c	LmjF32.3990	2,0 ^c
hypothetical	LinJ01_V3.0650	1,7 ^c	LmjF01.0630	2,5 ^c
hypothetical	LinJ06_V3.1030	2,1 ^c	LmjF06.0995	1,8 ^c
hypothetical	LinJ08_V3.0650	2,0 ^c	Lm jF08.0640	4,8 ^c
hypothetical	LinJ10_V3.1130	2,7 ^c	LmjF10.1050	1,8 ^c
hypothetical	LinJ12_V3.0440	1,9 ^c	Lm jF12.0480	5,1 ^c
hypothetical	LinJ16_V3.0100	1,9 ^c	Lm jF16.0090	2,5 ^c
hypothetical	LinJ24_V3.2320	2,7 ^c	LmjF24.2230	1,7 ^c
hypothetical	LinJ25_V3.2870	2,3 ^c	LmjF35.2820	1,8 ^c
hypothetical	LinJ26_V3.1440	1,8 ^c	Lm jF26.1460	2,0 ^c
hypothetical	LinJ27_V3.0770	20,8 ^c	Lm jF27.0910	1,9 ^c
hypothetical	LinJ27_V3.2320	2,5 ^c	LmjF27.2370	1,8 ^c
hypothetical	LinJ30_V3.0820	2,0 ^c	LmjF30.0770	1,8 ^c
hypothetical	LinJ30_V3.1000	7,1 ^c	LmjF30.0940	2,7 ^c
hypothetical	LinJ30_V3.2340	1,7 ^c	Lm jF30.2330	2,4 ^c
hypothetical	LinJ31_V3.1190	2,1 ^c	Lm jF31.1170	2,7 ^c
hypothetical	LinJ 31_V 3.2140	1,9 ^c	LmjF 31.2090	2,0 ^c
hypothetical	LinJ 32_V3.3600	1,9 ^c	LmjF 32.3400	2,3 ^c
hypothetical	LinJ 33_V3.1720	4,2 ^c	Lm jF 33.1620	4,5 ^c
hypothetical	LinJ 35_V3.5130	1,7 ^c	Lm jF 35.5160	1,8 ^c

^aGenes differentially expressed in promastigotes.

^bGenes differentially expressed but not in the same life stage.

^cGenes differentially expressed in amastigotes.

^dThe majority of the phosphoglycan 1,3 galactosyltransferase gene family members are differentially expressed in amastigotes. These genes are listed in Additional files 2 and 4.

^eThe majority of the amastin gene family members are differentially expressed in amastigotes. These genes are listed in Additional files 2 and 4.