Table 3.
Genes differentially expressed in Leishmania infantum but constitutively expressed in Leishmania major.
| GO annotation (molecular function) | Accession number (GeneDB) | Fold increase | Accession number (GeneDB) | Fold increase a |
| L. infantum | L. major | |||
| Metabolic process | ||||
| glycerolphosphate mutase | LinJ33_V3.2220 | 2,2 b | LmjF33.2100 | 1,4 |
| iron superoxide dismutase | LinJ32_V3.1920 | 1,9 b | LmjF32.1839 | 1,2 |
| proteasome alpha 7 subunit | LinJ27_V3.0190 | 1,9 b | LmjF27.0190 | 1,3 |
| pyruvate phosphate dikinase | LinJ11_V3.1000 | 1,8 b | LmjF11.1000 | 1,3 |
| nuclear receptor binding factor-like protein | LinJ05_V3.0520 | 2,1 c | LmjF05.0520 | 1,3 |
| quinone oxidoreductase | LinJ03_V3.0550 | 11,7 c | LmjF03.0570 | 1,0 |
| quinonoid dihydropteridine reductase | LinJ34_V3.4270 | 20,2 c | LmjF34.4330 | 1,0 |
| Response to oxidative stress | ||||
| ascorbate-dependent peroxidase | LinJ34_V3.0070 | 3,0 b | LmjF34.0070 | 1,6 |
| Carbohydrate metabolic process | ||||
| 6-phosphogluconate dehydrogenase, decarboxylating | LinJ35_V3.3390 | 2,0 b | LmjF35.3340 | 1,0 |
| pyruvate kinase | LinJ35_V3.5450 | 1,9 b | LmjF35.0030 | 1,4 |
| Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | ||||
| thymidine kinase | LinJ21_V3.1450 | 1,7 b | LmjF21.1210 | 1,3 |
| DNA-directed RNA polymerase, alpha subunit | LinJ19_V3.0660 | 1,9 c | LmjF19.0660 | 1,0 |
| nuclear cap binding protein | LinJ30_V3.0560 | 4,1 c | LmjF30.0540 | 1,1 |
| vacuolar ATP synthase subunit | LinJ12_V3.0480 | 1,7 c | LmjF12.0520 | 1,0 |
| DNA metabolic process | ||||
| kinetoplast DNA-associated protein | LinJ36_V3.6180 | 1,8 b | LmjF36.5920 | 1,1 |
| RNA metabolic process | ||||
| RNA binding protein | LinJ04_V3.1190 | 2,2 b | LmjF04.1170 | 1,0 |
| RNA binding protein UBP1 | LinJ25_V3.0500 | 2,1 b | LmjF25.0490 | 1,1 |
| RNA binding protein UBP2 | LinJ25_V3.0510 | 2,1 b | LmjF25.0500 | 1,1 |
| mRNA capping methyltransferase | LinJ36_V3.0130 | 7,3 c | LmjF36.0120 | 1,1 |
| pseudouridylate synthase-like | LinJ01_V3.0280 | 1,9 c | LmjF01.0280 | 1,1 |
| RNA-binding protein | LinJ17_V3.0610 | 1,7 c | LmjF17.0550 | 1,3 |
| RNase PH-like exosome associated protein 1 | LinJ20_V3.1400 | 2,0 c | LmjF20.1360 | 1,1 |
| Amino acid and derivative metabolic process | ||||
| glycine dehydrogenase | LinJ26_V3.0040 | 8,1 c | LmjF26.0030 | 1,4 |
| Protein metabolic process | ||||
| Proteolysis | ||||
| mitochondrial processing peptidase, beta subunit | LinJ35_V3.1390 | 2,1 b | LmjF35.1380 | 1,0 |
| aminopeptidase | LinJ19_V3.0150 | 1,7 c | LmjF19.0160 | 1,2 |
| aminopeptidase | LinJ33_V3.2700 | 4,7 c | LmjF33.2570 | 1,3 |
| mitochondrial ATP-dependent zinc metallopeptidase | LinJ34_V3.1130 | 3,6 c | LmjF34.1060 | 1,1 |
| Protein folding | ||||
| chaperone protein DNAJ | LinJ18_V3.1470 | 1,8 c | LmjF18.1490 | 1,1 |
| DNAJ protein | LinJ21_V3.0550 | 4,5 c | LmjF21.0490 | 1,0 |
| Protein modification process | ||||
| protein kinase | LinJ27_V3.0100 | 4,6 c | LmjF27.0100 | 1,0 |
| Electron transport | ||||
| oxidoreductase-like protein | LinJ19_V3.1490 | 1,7 b | LmjF19.1450 | 1,0 |
| trypanothione reductase | LinJ05_V3.0350 | 1,7 b | LmjF05.0350 | 1,1 |
| Transport | ||||
| mitochondrial carrier protein | LinJ35_V3.3380 | 1,8 b | LmjF35.3330 | 1,5 |
| LinJ28_V3.2050, | ||||
| zinc transporter | LinJ28_V3.2060 | 2,5 b | LmjF28.1930 | 1,2 |
| ABC transporter | LinJ29_V3.0640 | 4,8 c | LmjF29.0620 | 1,6 |
| ABC transporter | LinJ11_V3.0040 | 10,9 c | LmjF11.0040 | 1,3 |
| amino acid permease | LinJ36_V3.0450 | 30,9 c | LmjF36.0420 | 1,4 |
| pteridine transporter | LinJ06_V3.1320 | 2,8 c | LmjF06.1260 | 1,6 |
| Cellular component organization and biogenesis | ||||
| LinJ16._V3.1550, | ||||
| kinesin | LinJ16_V3.1570 | 1,8 b | LmjF16.1460 | 1,0 |
| kinesin | LinJ23_V3.0720 | 1,9 b | LmjF23.0560 | 1,1 |
| kinesin | LinJ25_V3.2050 | 3,8 c | LmjF25.1970 | 1,1 |
| Cell cycle | ||||
| cyclin-dependent kinase regulatory subunit | LinJ32_V3.3940 | 1,7 c | LmjF32.3790 | 1,0 |
| Cell communication | ||||
| phosphoinositide-binding protein | LinJ35_V3.2470 | 1,9 b | LmjF35.2420 | 1,2 |
| rab11B GTPase | LinJ32_V3.1930 | 1,8 b | LmjF32.1840 | 1,1 |
| Unclassified | ||||
| hypothetical | LinJ02_V3.0430 | 4,3 b | LmjF02.0460 | 1,4 |
| hypothetical | LinJ19_V3.0570 | 1,8 b | LmjF19.0540 | 1,3 |
| hypothetical | LinJ19_V3.0610 | 1,8 b | LmjF19.0610 | 1,1 |
| hypothetical | LinJ19_V3.1150 | 1,9 b | LmjF19.1160 | 1,2 |
| hypothetical | LinJ20_V3.0030 | 3,6 b | LmjF20.0030 | 1,1 |
| hypothetical | LinJ23_V3.0010 | 2,1 b | LmjF23.0010 | 1,6 |
| hypothetical | LinJ23_V3.1170 | 2,2 b | LmjF23.1000 | 1,3 |
| hypothetical | LinJ24_V3.2420 | 1,8 b | LmjF24.2330 | 1,2 |
| hypothetical | LinJ27_V3.1110 | 2,5 b | LmjF27.1230 | 1,3 |
| hypothetical | LinJ28_V3.0100 | 1,8 b | LmjF28.0100 | 1,3 |
| hypothetical | LinJ32_V3.0530 | 1,7 b | LmjF32.0500 | 1,3 |
| hypothetical | LinJ33_V3.1200 | 2,6 b | LmjF33.1140 | 1,1 |
| hypothetical | LinJ33_V3.2570 | 1,8 b | LmjF33.2440 | 1,0 |
| hypothetical | LinJ35_V3.0180 | 1,8 b | LmjF35.0180 | 1,3 |
| hypothetical | LinJ35_V3.4360 | 1,7 b | LmjF35.4290 | 1,2 |
| hypothetical | LinJ36_V3.5520 | 2,9 b | LmjF36.5290 | 1,1 |
| A-1 | LinJ29_V3.1020 | 2,4 c | LmjF29.0935 | 1,6 |
| dehydrogenase/oxidoreductase-like protein | LinJ02_V3.0700 | 2,0 c | LmjF02.0730 | 1,2 |
| EF hand-like protein | LinJ13_V3.1490 | 1,9 c | LmjF13.1450 | 1,3 |
| ferric reductase transmembrane protein | LinJ30_V3.2050 | 2,0 c | LmjF30.2050 | 1,2 |
| GTPase activator protein | LinJ29_V3.1670 | 7,1 c | LmjF29.1560 | 1,1 |
| leucine rich repeat protein | LinJ28_V3.2790 | 5,5 c | LmjF28.2580 | 1,0 |
| lipin | LinJ06_V3.0860 | 1,8 c | LmjF06.0830 | 1,0 |
| membrane-bound acid phosphatase | LinJ28_V3.2850 | 2,2 c | LmjF28.2650 | 1,4 |
| zinc-finger protein | LinJ30_V3.2350 | 2,4 c | LmjF30.2340 | 1,1 |
| metallopeptidase | LinJ16_V3.0850 | 8,9 c | LmjF16.0850 | 1,3 |
| hypothetical | LinJ01_V3.0820 | 2,3 c | LmjF01.0800 | 1,0 |
| hypothetical | LinJ03_V3.0060 | 3,0 c | LmjF03.0070 | 1,3 |
| hypothetical | LinJ04_V3.1150 | 7,7 c | LmjF04.1140 | 1,3 |
| hypothetical | LinJ07_V3.0390 | 2,1 c | LmjF07.0230 | 1,2 |
| hypothetical | LinJ08_V3.0170 | 1,9 c | LmjF08.0160 | 1,1 |
| hypothetical | LinJ12_V3.0710 | 1,8 c | LmjF12.1110 | 1,3 |
| hypothetical | LinJ13_V3.0230 | 2,7 c | LmjF13.0230 | 1,2 |
| hypothetical | LinJ14_V3.0560 | 24,6 c | LmjF14.0550 | 1,4 |
| hypothetical | LinJ15_V3.0510 | 8,5 c | LmjF15.0490 | 1,0 |
| hypothetical | LinJ15_V3.1000 | 4,7 c | LmjF15.0940 | 1,0 |
| hypothetical | LinJ16_V3.0620 | 5,2 c | LmjF16.0620 | 1,3 |
| hypothetical | LinJ16_V3.1260 | 11,6 c | LmjF16.1210 | 1,1 |
| hypothetical | LinJ17_V3.0600 | 2,4 c | LmjF17.0540 | 1,1 |
| hypothetical | LinJ18_V3.0120 | 1,9 c | LmjF18.0120 | 1,1 |
| hypothetical | LinJ18_V3.0300 | 3,0 c | LmjF18.0300 | 1,1 |
| hypothetical | LinJ19_V3.1170 | 9,0 c | LmjF19.1180 | 1,4 |
| hypothetical | LinJ20_V3.0450 | 1,8 c | LmjF20.0380 | 1,1 |
| hypothetical | LinJ20_V3.1670 | 3,3 c | LmjF20.1700 | 1,4 |
| hypothetical | LinJ21_V3.0920 | 4,6 c | LmjF21.0825 | 1,1 |
| hypothetical | LinJ21_V3.1220 | 5,1 c | LmjF21.0980 | 1,3 |
| hypothetical | LinJ22_V3.0110 | 1,8 c | LmjF22.0240 | 1,2 |
| hypothetical | LinJ23_V3.1520 | 2,3 c | LmjF23.1267 | 1,1 |
| hypothetical | LinJ24_V3.0700 | 8,2 c | LmjF24.0690 | 1,5 |
| hypothetical | LinJ24_V3.1080 | 4,0 c | LmjF24.1060 | 1,1 |
| hypothetical | LinJ24_V3.1620 | 1,9 c | LmjF24.1550 | 1,1 |
| hypothetical | LinJ25_V3.0220 | 11,0 c | LmjF25.0220 | 1,2 |
| hypothetical | LinJ25_V3.0460 | 5,0 c | LmjF25.0450 | 1,4 |
| hypothetical | LinJ25_V3.0560 | 32,7 c | LmjF25.0550 | 1,1 |
| hypothetical | LinJ26_V3.1260 | 1,9 c | LmjF26.1280 | 1,0 |
| hypothetical | LinJ26_V3.1850 | 2,8 c | LmjF26.1850 | 1,1 |
| hypothetical | LinJ26_V3.2220 | 6,5 c | LmjF26.2210 | 1,2 |
| hypothetical | LinJ27_V3.1080 | 2,8 c | LmjF27.1200 | 1,1 |
| hypothetical | LinJ29_V3.0930 | 46,7 c | LmjF29.0868 | 1,5 |
| hypothetical | LinJ30_V3.0160 | 12,4 c | LmjF30.0170 | 1,2 |
| hypothetical | LinJ31_V3.0490 | 5,4 c | LmjF31.0470 | 1,3 |
| hypothetical | LinJ31_V3.1630 | 2,2 c | LmjF31.1600 | 1,0 |
| hypothetical | LinJ32_V3.1410 | 2,2 c | LmjF32.1350 | 1,1 |
| hypothetical | LinJ32_V3.3760 | 2,9 c | LmjF32.3600 | 1,2 |
| hypothetical | LinJ33_V3.0590 | 1,8 c | LmjF33.0565 | 1,3 |
| hypothetical | LinJ33_V3.0810 | 2,1 c | LmjF33.0760 | 1,1 |
| hypothetical | LinJ33_V3.2850 | 1,9 c | LmjF33.2710 | 1,4 |
| hypothetical | LinJ34_V3.2250 | 2,0 c | LmjF34.2473 | 1,2 |
| hypothetical | LinJ34_V3.3520 | 4,1 c | LmjF34.3730 | 1,1 |
| hypothetical | LinJ35_V3.4090 | 10,3 c | LmjF35.4040 | 1,2 |
| hypothetical | LinJ35_V3.1640 | 9,4 c | LmjF35.1640 | 1,2 |
| hypothetical | LinJ35_V3.5350 | 2,1 c | LmjF35.5030 | 1,0 |
| hypothetical | LinJ36_V3.0470 | 6,3 c | LmjF36.0440 | 1,1 |
| hypothetical | LinJ36_V3.4410 | 3,5 c | LmjF36.4200 | 1,6 |
| hypothetical | LinJ36_V3.4940 | 1,8 c | LmjF36.4710 | 1,1 |
a Only non-modulated genes are listed in this column.
b Genes differentially expressed in promastigotes.
c Genes differentially expressed in amastigotes.