TABLE 1.
PKC-mediated IRS-1 phosphorylation
| Action | Effect | Reference | |
|---|---|---|---|
| PKCα | IRS-1 Ser/Thr phosphorylation | Inhibition of IR kinase activity | 30 |
| IRS-1 Ser24 phosphorylation | Reduced IRS-1 phosphatidylinositol-4,5-bisphosphate binding | 31 | |
| PKCδ | IRS-1 Ser/Thr phosphorylation | Inhibition of IR kinase activity | 30 |
| IRS-1 Ser307,323,574 phosphorylation | Reduced IRS-1 Tyr phosphorylation | 32 | |
| IRS-1 Ser24 phosphorylation | Reduced IRS-1 phosphatidylinositol-4,5-bisphosphate binding | 33 | |
| IRS-1 Ser318 phosphorylation | Early positive but longer-term negative regulation of IRS-1 signaling | 34 | |
| IRS-1 Ser357 phosphorylation | Reduced IRS-1 Tyr phosphorylation | 35 | |
| PKCθ | IRS-1 Ser/Thr phosphorylation | Inhibition of IR kinase activity | 30 |
| IRS-1 Ser1101 phosphorylation | Reduced IRS-1 Tyr phosphorylation | 36 | |
| PKCζ | IRS-1 Ser/Thr phosphorylation | Reduced IRS-1 Tyr phosphorylation | 37,38 |
| IRS-1 Ser318 phosphorylation | Reduced IRS-1 Tyr phosphorylation | 39,40 |
IRS-1 phosphorylation sites are listed as they appear in individual references. Ser302, 307, and 318 in mouse IRS-1 are Ser307, 312, and 323 in human IRS-1. IR, insulin receptor.