TABLE 3.
Association between rs1044498 (K121Q) and diabetes-related quantitative traits
| Trait | KK | KQ | Percent variance explained |
P value |
|||
|---|---|---|---|---|---|---|---|
| Additive | Recessive | Dominant | |||||
| n | 1,982 | 695 | 74 | ||||
| FPG (mg/dl) | 99 ± 23.9 | 101 ± 29.6 | 107 ± 43.0 | 0.17 (0.11) | 0.01 (0.02) | 0.07 (0.16) | 0.02 (0.03) |
| A1C (%) | 5.39 ± 0.93 | 5.48 ± 1.02 | 5.72 ± 1.24 | 0.40 (0.30) | 0.006 (0.01) | 0.03 (0.03) | 0.02 (0.03) |
| Mean FPG (mg/dl) | 99.1 ± 19.92 | 99.6 ± 21.23 | 101 ± 21.5 | 0.005* | 0.21 (0.26) | 0.42 (0.63) | 0.25 (0.27) |
| Fasting insulin (μU/ml) | 29.5 ± 11.57 | 31.3 ± 13.87 | 31.2 ± 12.09 | 0.32 (0.22) | 0.006 (0.01) | 0.58 (0.96) | 0.003 (0.006) |
| HOMA-IR | 7.5 ± 4.71 | 8.06 ± 5.43 | 8.05 ± 4.37 | 0.29 (0.19) | 0.006 (0.01) | 0.56 (0.95) | 0.004 (0.005) |
| HOMA-B | 343.8 ± 179.4 | 329.1 ± 444.7 | 336.8 ± 136.6 | 0.04 (0.03) | 0.40 (0.49) | — | — |
| Gutt's ISI | 25.8 ± 7.36 | 25.4 ± 7.76 | 26.3 ± 7.42 | 0.03 (0.01) | 0.31 (0.42) | 0.29 (0.15) | 0.12 (0.15) |
| Waist circumference (inches) | 36.5 ± 5.55 | 36.4 ± 5.93 | 37.6 ± 6.01 | 0.02 (0.04) | 0.64 (0.35) | 0.43 (0.93) | 0.80 (0.30) |
| BMI (kg/m2) | 27.4 ± 4.83 | 27.5 ± 5.19 | 28.4 ± 6.26 | 0.06 | 0.32 | 0.42 | 0.40 |
All quantitative trait values are unadjusted means ± SD, with P values without parentheses adjusted for sex and age and P values in parentheses additionally adjusted for BMI. Associations between rs1044498 (K121Q) and selected quantitative metabolic traits in the FHS, with P values for the additive, recessive, and dominant genetic models are shown. The major (A) and minor (C) alleles code for the amino acids lysine (K) and glutamine (Q), respectively. The MAF is 15% in Framingham. Mean FPG, FPG averaged over exams 3–7 comprising 16 years; Gutt's ISI, Gutt's insulin sensitivity index.
*
The variance due to K121Q was not estimable because of instability.