TABLE 2.

Measurement of AGEs in diabetic RAGE KO mice hearts under baseline normoxic and I/R conditions

		Wild-type-DM	RAGE-KO-D	Tg DN PPET-D	Tg DN MSR-D
CML	B	34.88 ± 4.46	21.73 ± 1.25*	31.92 ± 4.67	39.44 ± 7.87
	I/R	41.83 ± 5.48†	24.63 ± 3.44	22.73 ± 1.25	27.86 ± 4.88
Pentosidine	B	191.16 ± 27.97	137.67 ± 20.61‡	197.37 ± 38.02	209 ± 49.57
	I/R	190.65 ± 44.83	105.66 ± 20.55§	180.46 ± 34.71	116.52 ± 29.07§
Furosine	B	135.51 ± 7.79	98.07 ± 2.40¶	126.76 ± 9.31	121.58 ± 11.32
	I/R	123.30 ± 4.76	101.81 ± 8.05‖	107.87 ± 5.09‖	129.77 ± 9.94

Data are means ± SD.

^*P < 0.05 RAGE-KO-D vs. all other groups for CML comparison.

^†P < 0.05 wild-type-DM vs. all other groups for CML comparison.

^‡P < 0.05 RAGE-KO-D vs. all other groups for pentosidine comparison.

^§P < 0.05 RAGE-KO-D, DNMSR vs. all other groups for pentosidine comparison.

^¶P < 0.05 RAGE-KO-D vs. all other groups for furosine comparison.

^‖P < 0.05 RAGE-KO-D, DNPPET vs. all other groups for furosine comparison. CML and furosine are expressed as μmol/mol lysine, whereas pentosidine is expressed as fmol/mg protein.