FIG. 4.

CNTO736 decreases food intake and delays gastric emptying. A: Fasted GLP-1 receptor knockout (n = 5) (▪) or C57BL/6 mice (n = 6) (□) were dosed subcutaneously with CNTO736 (1 mg/kg) or a negative control (1 mg/kg). Food intake was monitored over 24 h. The results are presented as the means ± SE (n = 5). *P value <0.05. B: Fasted mice (n = 5) were given a preweighed meal and the amount of food consumed in 1 h was measured. The mice were dosed intravenously with CNTO736 (2.4 mg/kg) or vehicle and were killed after 4 h. The wet weight of the stomach contents was measured to determine what percent of the food remained in the stomach as an estimate of gastric emptying. The results are presented as means ± SE (n = 10). *P value <0.05.