Table 3—
Comparison of cardiovascular risk factors in individuals with different insulin responses but within the same insulin sensitivity quartile
| SSPG quartile 1: insulin sensitive
|
SSPG quartile 4: insulin resistant
|
|||||
|---|---|---|---|---|---|---|
| Insulin response quartile 1 | Insulin response quartile 2 | P value | Insulin response quartile 3 | Insulin response quartile 4 | P value | |
| n | 72 | 31 | 27 | 79 | ||
| Insulin response (pmol · l−1 · 3 h−1) | 484 (390–552) | 738 (689–853) | <0.001 | 1,233 (1,075–1,422) | 2,441 (1,870–2,931) | <0.001 |
| SSPG (mmol/l) | 3.3 ± 0.8 | 3.8 ± 0.7 | 0.004 | 13.5 ± 1.5 | 14.8 ± 1.7 | 0.001 |
| Age (years) | 45 ± 12 | 46 ± 11 | 0.93 | 49 ± 14 | 53 ± 11 | 0.24 |
| Sex (% male) | 46 | 45 | 0.95 | 59 | 51 | 0.44 |
| Non-Hispanic white | 92 | 94 | 0.74 | 89 | 86 | 0.71 |
| BMI (kg/m2) | 23 ± 3 | 24 ± 3 | 0.47 | 29 ± 5 | 31 ± 4 | 0.07 |
| Fasting glucose (mmol/l) | 4.8 ± 0.6 | 4.9 ± 0.4 | 0.34 | 5.4 ± 0.8 | 5.5 ± 0.6 | 0.65 |
| Fasting insulin (pmol/l) | 42 (35–56) | 56 (42–69) | 0.08 | 97 (76–111) | 132 (104–181) | <0.001 |
| Total cholesterol (mmol/l) | 4.5 ± 0.7 | 4.8 ± 1.0 | 0.08 | 5.2 ± 0.9 | 5.2 ± 0.9 | 0.78 |
| Triglyceride (mmol/l) | 0.75 (0.60–0.92) | 0.93 (0.67–1.10) | 0.08 | 1.75 (1.25–2.25) | 1.81 (1.41–2.46) | 0.18 |
| HDL cholesterol (mmol/l) | 1.5 ± 0.4 | 1.4 ± 0.4 | 0.75 | 1.3 ± 0.3 | 1.1 ± 0.2 | <0.001 |
| LDL cholesterol (mmol/l) | 2.7 ± 0.7 | 3.0 ± 1.0 | 0.12 | 3.1 ± 0.8 | 3.2 ± 0.8 | 0.73 |
| Systolic blood pressure (mmHg) | 122 ± 19 | 117 ± 16 | 0.21 | 143 ± 23 | 140 ± 19 | 0.52 |
| Diastolic blood pressure (mmHg) | 72 ± 10 | 74 ± 10 | 0.33 | 88 ± 12 | 86 ± 11 | 0.54 |
Data are means ± SD, median (interquartile range), or percent.