Table 2—

HRs (95% CI) of foot ulcer and LEA for the full dataset and for foot ulcer and LEA

A. Full dataset	Foot ulcer	Foot ulcer adjusted	LEA	LEA adjusted (includes an interaction term for PAD)
CKD (eGFR)
≥60 ml/min per 1.73 m2	Ref	Ref	Ref	Ref
≥30 to <60 ml/min per 1.73 m2	1.85 (1.71–2.01)	1.51 (1.38–1.66)	2.08 (1.68–2.58)	2.28 (1.54–3.36)
<30 ml/min per 1.73 m2	3.92 (3.23–4.75)	3.22 (2.60–4.00)	7.71 (5.29–1.26)	8.05 (4.23–7.01)

B. Foot ulcer	Foot ulcer without PAD	Foot ulcer without PAD adjusted	Foot ulcer with PAD	Foot ulcer with PAD adjusted
CKD (eGFR)
≥60 ml/min per 1.73 m2	Ref	Ref	Ref	Ref
≥30 to <60 ml/min per 1.73 m2	1.68 (1.51–1.86)	1.41 (1.24,1.58)	1.44 (1.26,1.65)	1.38 (1.18–1.60)
<30 ml/min per 1.73 m2	3.86 (3.00–4.98)	3.32 (2.55–4.33)	2.10 (1.56,2.84)	2.04 (1.49–2.79)

C. LEA	LEA without PAD	LEA without PAD adjusted	LEA with PAD	LEA with PAD adjusted
CKD (eGFR)
≥60 ml/min per 1.73 m2	Ref	Ref	Ref	Ref
≥30 to <60 ml/min per 1.73 m2	1.82 (1.28–2.60)	2.05 (1.37–3.07)	1.31 (1.00–1.72)*	1.60 (1.19–2.16)
<30 ml/min per 1.73 m2	6.96 (3.50–13.83)	7.80 (3.82–15.90)	2.90 (1.76,4.76)	3.33 (1.93–5.77)

Adjusted and unadjusted results are shown. Parts B and C include results in the presence or absence of peripheral arterial disease. Compared with reference (Ref) or as a test for trend, all P values <0.001 unless

^*P = 0.05.