Table 3—
Association between adiponectin and incident type 2 diabetes with addition of leptin, CRP, IL-6, and/or SAA: the Sandy Lake Health and Diabetes Project
| Adiponectin | Leptin | CRP | IL-6 | SAA | C Statistic* | |
|---|---|---|---|---|---|---|
| Base model† | 0.45 (0.25–0.81) | 0.753 | ||||
| + Leptin | 0.45 (0.25–0.81) | 0.98 (0.55–1.74) | 0.753 | |||
| + CRP | 0.45 (0.25–0.81) | 0.99 (0.77–1.26) | 0.753 | |||
| + IL-6 | 0.45 (0.25–0.81) | 0.98 (0.74–1.31) | 0.753 | |||
| + SAA | 0.46 (0.26–0.81) | 1.07 (0.79–1.47) | 0.754 | |||
| + Leptin + CRP | 0.45 (0.25–0.81) | 1.00 (0.97–1.03) | 0.98 (0.77–1.26) | 0.753 | ||
| + Leptin + CRP + IL-6 | 0.45 (0.25–0.81) | 1.00 (0.97–1.03) | 0.99 (0.76–1.28) | 0.99 (0.72–1.35) | 0.753 | |
| + Leptin + CRP + IL-6 + SAA | 0.45 (0.25–0.81) | 1.00 (0.97–1.03) | 0.95 (0.70–1.27) | 0.97 (0.71–1.33) | 1.13 (0.77–1.65) | 0.755 |
Data are OR (95% CI) per 1-unit change (n = 479).
*
There were no significant differences between the C statistics of the baseline model and subsequent models adjusted with additional adipokine(s).
†
Outcome = incident diabetes; 1° exposure = adiponectin, with adjustment for age, sex, triglyceride, HDL cholesterol, hypertension, impaired glucose tolerance, and waist circumference.