Table 2.
Differentially expressed genes in sigmoid colon mucosal biopsies from IBS patients compared to healthy controls.
Affymetrix probe set | Gene symbol | q-value SAM | q-value ANOVA | Fold change | Gene annotation |
---|---|---|---|---|---|
HIGHER expression in IBS patients versus controls | |||||
225809_at | DKFZP564O0823 | 0.018 | 0.03 | 1.41 | DKFZP564O0823 (IBS1) |
204687_at | DKFZP564O0823 | 0.018 | 0.01 | 1.24 | DKFZP564O0823 (IBS1) |
226622_at | MUC20 | 0.018 | 0.05 | 1.52 | Mucin 20 |
229369_at | VSIG2 | 0.023 | 0.01 | 1.20 | V-set and immunoglobulin domain containing, 2 |
231941_s_at | MUC20 | 0.030 | 0.07 | 1.47 | Mucin 20 |
200884_at | CKB | 0.039 | 0.05 | 1.29 | Creatine kinase, brain |
LOWER expression in IBS patients versus controls | |||||
223655_at | M160 | 0.018 | 0.05 | 0.69 | Scavenger receptor cysteine-rich type 1 protein M160 (CD163 antigen-like 1) |
204787_at | VSIG4 | 0.023 | 0.05 | 0.66 | V-set and immunoglobulin domain containing, 4 |
211368_s_at | CASP1 | 0.030 | 0.05 | 0.75 | Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) |
205147_x_at | NCF4 | 0.030 | 0.05 | 0.70 | Neutrophil cytosolic factor 4, 40kDa |
1555745_a_at | LYZ | 0.030 | 0.11 | 0.48 | Lysozyme |
205968_at | KCNS3 | 0.039 | 0.10 | 0.66 | Potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 |
211367_s_at | CASP1 | 0.039 | 0.06 | 0.75 | Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) |
201762_s_at | PSME2 | 0.045 | 0.01 | 0.84 | Proteasome activator subunit 2 (PA28 beta) |
211366_x_at | CASP1 | 0.049 | 0.06 | 0.76 | Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) |
219607_s_at | MS4A4A | 0.056 | 0.13 | 0.74 | Membrane-spanning 4-domains, subfamily A, member 4 |
220085_at | HELLS | 0.058 | 0.07 | 0.82 | Helicase, lymphoid-specific |
1552703_s_at | COP1 | 0.080 | 0.06 | 0.81 | Caspase 1 dominant-negative inhibitor pseudo-ICE |
203561_at | FCGR2A | 0.080 | 0.08 | 0.77 | Fc fragment of IgG, low affinity IIa, receptor (CD32) |
204023_at | RFC4 | 0.084 | 0.06 | 0.83 | Replication factor C (activator 1) 4, 37kDa |
206011_at | CASP1 | 0.084 | 0.11 | 0.77 | Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) |
216237_s_at | MCM5 | 0.084 | 0.08 | 0.76 | MCM5 mini-chromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) |
225973_at | TAP2 | 0.084 | 0.16 | 0.71 | Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) |
219759_at | LRAP | 0.084 | 0.21 | 0.39 | Leukocyte-derived arginine aminopeptidase |
218585_s_at | DTL | 0.084 | 0.11 | 0.79 | Denticleless homolog (Drosophila) |
The shown data are limited to gene probe sets with q<0.1 in the SAM analysis. Fold change values indicate the ratio of the mean gene expression in IBS patients compared to healthy controls.