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. Author manuscript; available in PMC: 2009 Feb 1.
Published in final edited form as: Clin Gastroenterol Hepatol. 2008 Feb;6(2):194–205. doi: 10.1016/j.cgh.2007.11.012

Table 2.

Differentially expressed genes in sigmoid colon mucosal biopsies from IBS patients compared to healthy controls.

Affymetrix probe set Gene symbol q-value SAM q-value ANOVA Fold change Gene annotation
HIGHER expression in IBS patients versus controls

225809_at DKFZP564O0823 0.018 0.03 1.41 DKFZP564O0823 (IBS1)
204687_at DKFZP564O0823 0.018 0.01 1.24 DKFZP564O0823 (IBS1)
226622_at MUC20 0.018 0.05 1.52 Mucin 20
229369_at VSIG2 0.023 0.01 1.20 V-set and immunoglobulin domain containing, 2
231941_s_at MUC20 0.030 0.07 1.47 Mucin 20
200884_at CKB 0.039 0.05 1.29 Creatine kinase, brain

LOWER expression in IBS patients versus controls

223655_at M160 0.018 0.05 0.69 Scavenger receptor cysteine-rich type 1 protein M160 (CD163 antigen-like 1)
204787_at VSIG4 0.023 0.05 0.66 V-set and immunoglobulin domain containing, 4
211368_s_at CASP1 0.030 0.05 0.75 Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
205147_x_at NCF4 0.030 0.05 0.70 Neutrophil cytosolic factor 4, 40kDa
1555745_a_at LYZ 0.030 0.11 0.48 Lysozyme
205968_at KCNS3 0.039 0.10 0.66 Potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
211367_s_at CASP1 0.039 0.06 0.75 Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
201762_s_at PSME2 0.045 0.01 0.84 Proteasome activator subunit 2 (PA28 beta)
211366_x_at CASP1 0.049 0.06 0.76 Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
219607_s_at MS4A4A 0.056 0.13 0.74 Membrane-spanning 4-domains, subfamily A, member 4
220085_at HELLS 0.058 0.07 0.82 Helicase, lymphoid-specific
1552703_s_at COP1 0.080 0.06 0.81 Caspase 1 dominant-negative inhibitor pseudo-ICE
203561_at FCGR2A 0.080 0.08 0.77 Fc fragment of IgG, low affinity IIa, receptor (CD32)
204023_at RFC4 0.084 0.06 0.83 Replication factor C (activator 1) 4, 37kDa
206011_at CASP1 0.084 0.11 0.77 Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
216237_s_at MCM5 0.084 0.08 0.76 MCM5 mini-chromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
225973_at TAP2 0.084 0.16 0.71 Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
219759_at LRAP 0.084 0.21 0.39 Leukocyte-derived arginine aminopeptidase
218585_s_at DTL 0.084 0.11 0.79 Denticleless homolog (Drosophila)

The shown data are limited to gene probe sets with q<0.1 in the SAM analysis. Fold change values indicate the ratio of the mean gene expression in IBS patients compared to healthy controls.

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