Table 1.

Spectrum of base-substitutional mutations

Method	Transitions		Transversions				N
	A:T → G:C	G:C → A:T	A:T → T:A	G:C → T:A	A:T → C:G	G:C → C:G
SUP4-o*	0.127	0.266	0.044	0.314	0.043	0.207	798
CAN1†‡	0.094	0.358	0.075	0.269	0.066	0.137	212
URA3*‡	0.022	0.241	0.149	0.351	0.057	0.175	228
Summary	0.102	0.277	0.069	0.313	0.050	0.189	1238
Nu, this study	0.118	0.265	0.059	0.265	0.147	0.147	34
Mt, this study	0.476	0.000	0.333	0.000	0.191	0.000	21

The first three rows summarize results from prior studies using single-locus reporter constructs in the nucleus, and the fourth row summarizes these data. Nu, nuclear; Mt, mitochondrial.

*ref. 49.

^†ref. 50.

^‡ref. 12.