Fig. 3.

Evoked perforant path synaptic transmission in Mef2C^BKO/KO. Lateral perforant path was stimulated by a 10- to 40-μA current pulse to evoke ESPCs at perforant path-dentate granule cell synapses. Representative examples of current voltage of glutamate-evoked response from single AMPA (A Upper) or NMDA (B Upper) synapses from WT and MEF2C-deficient neurons. Bar graph showing increased amplitude in both AMPA (A; V_m = −70 mV) and NMDA (B; V_m = +40 mV) mediated evoked EPSCs in granule cells of dentate gyrus of Mef2C^BKO/KO mice. Asterisk indicates statistical significance in pairwise comparison: P < 0.0005. (C) The AMPA/NMDA ratios were similar in WT and Mef2C^BKO/KO mice. (D) Input–output curves showing increase in the saturation of AMPA receptor in dentate gyrus neurons lacking MEF2C (open triangles).