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. 2008 Jul 1;105(27):9391–9396. doi: 10.1073/pnas.0802679105

Fig. 4.

Fig. 4.

Synaptic function is altered in NSE-MEF2C-VP16 transgenic mice. (A) (Upper) Representative traces of whole-cell patch–clamp recordings demonstrating spontaneous EPSCs from dentate granule cells (n = 24 for WT and n = 26 for NSE-MEF2C-VP16 transgenic mice). Bar graph showing a decrease in mEPSC frequency for dentate gyrus neurons in NSE-MEF2C-VP16 transgenic mice when compared to WT littermate controls. mEPSC amplitudes are unaffected in dentate gyrus neurons of the transgenic mice. (B) Paired-pulse facilitation at perforant path synapses also appeared normal in the transgenic mice. (C) Input–output curves showing decreased saturation of AMPA receptor in dentate gyrus neurons expressing the superactive MEF2C-VP16.