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. 2008 Jul 1;105(27):9302–9306. doi: 10.1073/pnas.0803520105

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© 2008 by The National Academy of Sciences of the USA

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Fig. 1. — H2ax/Atm double-deficient mice are embryonic lethal at E12.5. (A) Genotype of embryos obtained from timed breeding between HA^+/− parental mice. The other genotypes include H2ax^+/−, Atm^+/−, H2ax^+/−Atm^−/−, and H2ax^−/−Atm^+/− generated because of mitotic cross-over. (B) Morphology of representative E9.5, E10.5, and E11.5 WT and HA^−/− embryos. The magnifications for the objective lenses used are marked at the upper right corner of each picture. (C) Morphology of representative E10.5 WT, HA^−/−, Atm^−/−, and H2ax^−/− embryos. Right side view is shown. (Magnification, ×1.25.)