Table 1.

Maximized parametric analysis of potential human SLE susceptibility loci

Lod (θ, α)	Chromosomal location	Marker	Ped Grp	Model (penetrance)	GH	ASP
3.50 (0.15, 1.00)	1q41	D1s3462	AA	D (100, 96)
3.45 (0.00, 0.55)*	1q23	FcγRIIA	All	R (18, 1)	X	X
3.37 (0.00, 1.00)*	1q23	FcγRIIA	AA	R (85, 60)		X
2.50 (0.00, 0.25)	13q32	D13s779	All	R (100)
2.49 (0.00, 0.23)	20q13	D20s481	All	R (100)	X	X
2.21 (0.10, 1.00)	14q11	D14s742	EA	D (81, 1)
2.18 (0.07, 1.00)	4p15	D4s403	EA	D (37)	X	X
2.15 (0.00, 0.25)	11q25	D11s912	EA	R (100, 1)	X
2.10 (0.00, 0.35)	11q14–23	D11s2002	AA	D (100, 68)		X
2.09 (0.00, 1.00)	2q32	D2s1391	EA	D (21)	X	X
2.05 (0.00, 0.19)	19q13	D19s246	EA	R (100)
2.04 (0.00, 0.30)	6q26–27	D6s1027	EA	D (98)
2.04 (0.25, 1.00)	1q31	lamc1	All	D (95, 75)		X
2.01 (0.00, 0.30)	12p12–11	D12s1042	EA	R (65)	X	X
1.88 (0.00, 0.62)	21q21	D21s1437	EA	D (61)	X
1.87 (0.20, 1.00)	11p13	D11s1392	AA	D (98, 68)
1.68 (0.10, 0.59)	3p21	D3s1766	AA	R (100)

Penetrances of the dominant (D) or recessive (R) screening models were maximized for loci with lod > 1.5 and are given in parentheses as one value for both females and males or two values (female, male penetrance). The pedigree group (Ped Grp) is listed for African-American (AA), European-American (EA), or the entire pedigree collection (All). The maximum lod score is followed by θ, the recombination fraction and α, the proportion of linked pedigrees. Markers where nonparametric multipoint linkage (NPL statistic) from genehunter-plus (GH) or where affected sib-pair (ASP) analysis supported linkage at P < 0.05 are indicated (X). 

^*Maximized models for both All and AA are presented for FcγRIIA.