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Breeding scheme to generate the SCA mouse. The four different loci in the mice are depicted by the four boxes. Heterozygous and homozygous knockouts of the mouse α (mα) and mouse β (mβ) are indicated by +/− and −/−, and hemizygous and homozygous transgenes of the human α (ha) and human βs (hβs) are indicated by +/o and +/+, respectively.
