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DMBA–DNA adducts in DMBA-treated C3H mice
| Days after [3H]- DMBA treatment | Covalent binding, pmol/mg DNA
|
Percent fewer DMBA–DNA adducts in C3H.SW mice | |
|---|---|---|---|
| C3H/HeN | C3H.SW | ||
| 1 | 117.2 ± 2.4 | 145.5 ± 2.0 | 19* |
| 10 | 8.6 ± 0.4 | 16.9 ± 0.6 | 49* |
[3H]DMBA was applied topically to the skin of mice. On the indicated day, the skin was removed and the covalent binding of [3H]DMBA to DNA was determined. ∗, significantly different at the P < 0.01 level.
