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. Author manuscript; available in PMC: 2008 Jul 11.
Published in final edited form as: Cancer Gene Ther. 2006 Feb;13(2):115–124. doi: 10.1038/sj.cgt.7700896

Figure 3.

Figure 3

Summary of the overall network of suppression factors that are under the direct control of Egr-1: TGFβ1, PTEN, p53 and fibronectin. The solid arrows from Egr1 indicate regulation of target genes by direct promoter binding known in one or more human cell types to be under the direct regulation by Egr1. The subsequent downstream interactions have been observed in one or more of these systems except the potential roles of the Inks, Akt, and Kip1 which are taken from known interactions in other systems.