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. Author manuscript; available in PMC: 2008 Jul 11.
Published in final edited form as: Cancer Gene Ther. 2006 Feb;13(2):115–124. doi: 10.1038/sj.cgt.7700896

Table 1.

Evidence for the Regulation of Key Suppressor and Growth Modulating Factors by Egr-1

Suppressor Factor/Growth Regulator System Mechanism1 References
TGFβ1 Human fibrosarcoma cells, H T1080 Direct Liu 1996; de Belle 2000 5, 6
Transgenic mouse lung tissue Indirect Lee 2004 11
Vascular smooth muscle cells Indirect Fu 2003 83
In vivo mouse arterial stress model Indirect Sho 2002 84
Human nonsmall cell lung carcinoma cells Indirect Kane 2002 85
Airway smooth muscle cell preparation Indirect McKay 1998 86
Monkey kidney, CV-1 cells Direct Dey 1994 4
PTEN Human 293T fibroblasts Direct Virolle 2001 19
Mouse Embryo Fibroblasts Direct Virolle 2001 19
Human squamous carcinoma cells (SDCCTF) Indirect Okamura 2005 24
normal FRTL-5 rat thyroid cells, vs. thyroid tumor cell lines, ARO & BCPAP Indirect Tell 2004 23
Fetal kidney epithelial cells Indirect Tsugawa 2003 20
Mouse mammary gland in vivo Direct Moorehead 2003 21
Human prostate, DU145 & lung H226 carcinoma cells Indirect Han 2003 22
BCL-2 v-sis-transformed mouse NIH-3T3 cells Indirect Huang 1998 87
p53 Wild type and Egr-1 (−/−) mouse embryo fibroblasts Direct Krones-Herzig, Mittal 2005 35
Wild type and Egr-1 (−/−) mouse embryo fibroblasts Indirect Krones-Herzig 2003 34
Fresh surgical human glioblastoma series Indirect Calogero 2001 14
Wild type and Egr-1 (−/−) mouse embryo fibroblasts Indirect Krones-Herzig 2001 88
B-cell lymphoma cells BKS-2 from CBA mice Indirect Han 1999 89
Human A375-C6 melanoma cells Direct Ahmed 1996 90
Mouse NIH-3T3 cells Indirect Huang 1995 91
p73 Human genomic DNA Indirect Ding 1999 37
Murine cells, Neuro-2A cells Indirect Pignatalli 2003 38
Human cells, HI299 Indirect Kartecheva 2003 39
Fibronectin Human fibrosarcoma cells, HT1080 Direct Liu 1999 7
Human Glioblastoma, U251 cells Direct Liu 2000 13
Human surgical glioblastoma and primary cell lines Indirect Calogero 2004 15
Human fibrosarcoma cells, HT1080 Indirect de Belle 1999 43
1

“Direct” that there is experimental evidence that Egr1 binds the promoter in question at regulatory sequences to affect transcription whereas as indirect refers to published data consistent with a regulator role of Egr1 over the level of the factor without explicit demonstration of the mechanism of regulation.