Figure 4.

Chromosomal localization of the GABA_BR1 gene. Metaphase chromosomes were hybridized with digoxigenin-UTP-labeled probes derived from genomic PAC and BAC clones corresponding to the human and mouse GABA_BR1 gene, respectively. Localization of the mouse gene to chromosome (Chr) 17 (arrowheads) was confirmed by cohybridization with a telomer-selective biotin-labeled probe. Hybridization of the human gene to the mid arm of chromosome (Chr) 6 (arrowheads) was confirmed by cohybridization with a centromer-selective biotin-labeled probe. A total of 80 metaphases for each species were analyzed.