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. 1998 Dec 8;95(25):14997–15002. doi: 10.1073/pnas.95.25.14997

Figure 2.

Figure 2

NGF effect on synaptic transmission involves tyrosine phosphorylation. Pre- and postsynaptic potentials before and after extracellular application of 100 ng/ml of NGF. NGF was superfused after the postsynaptic terminal had been microinjected with 10 μM genistein (A) or cells had been preincubated for 10 min with 100 nM KT 252a. (B) NGF was applied at the same concentration as in A in cells preincubated for 10 min with 20 μM SU4984 (C) or 20 μM SU5402 (D). Shown are traces before and after NGF superfusion at the indicated times. Note that SU5402 did not block the NGF effect on synaptic transmission and that none of the tyrosine kinase inhibitors affected pre- or postsynaptic spike generation.