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. 1998 Dec 8;95(25):15026–15031. doi: 10.1073/pnas.95.25.15026

Figure 2.

Figure 2

LTP in hippocampal slices from wild-type and mutant mice. LTP was induced in each of four hippocampal regions (A–D). • represent data from wild-type slices, whereas ○ represent data from mutant slices. Each graph plots the percent increase in extracellular excitatory postsynaptic transmissions recorded before and after LTP induction; error bars represent the SEM. For each animal, 2–4 slices were examined; n refers to the number of animals per group. (A) Attenuated LTP in slices from mutant animals is observed only in the medial perforant path-to-dentate granule cell synapse (n = 9 wild type, 8 mutant). (B) LTP at mossy fiber-CA3 synapse (n = 7 wild type, 7 mutant). (C) CA3-to-CA1 LTP (n = 5 wild type, 5 mutant). (D) CA1-to-subiculum LTP (n = 5 wild type, 5 mutant). Traces above each graph show representative examples of field potentials from mutant and wild-type slices before and 30 min after LTP induction. Paired pulses were delivered 50 msec apart. Calibrations apply to all EPSPs.