Figure 3.

MWM task. In the hidden-platform phase of the task (A), escape latencies between mutant (n = 10, ○) and wild-type (n = 10, •) animals did not differ significantly. In contrast, mutant animals differed significantly from wild-type animals in the probe test (B). The number of times animals crossed the trained-platform location or its untrained equivalent in the other three quadrants was assessed. Whereas wild-type animals displayed significantly fewer (P < 0.05) crossings in the three untrained sites relative to the trained site, mutants did not exhibit a preference for the trained site (P > 0.05 for differences between the trained and each untrained site). In the visible-platform phase (C), mutants did not differ from wild types in escape latency (F_1,17 = 0.1, P > 0.05).