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Thermoregulatory responses to the administration of 8-OH-DPAT. Mean (±SEM) reduction in body temperature 20 min posttreatment (vehicle or 0.05, 0.2, 1.0 mg/kg 8-OH-DPAT; SC). Significant differences are indicated as ∗∗∗, P ≤ 0.001; ∗∗, P ≤ 0.01.
