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. 2008 Jun 23;6:33. doi: 10.1186/1479-5876-6-33

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Copyright © 2008 Lang and McCullough; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of estrogen on infarction volume in PARP-/- females. Physiological levels of E2 were restored to ovariectomized (OVX) PARP-/- and WT female mice. WT females had significant reductions in total, cortical (CTX) and striatal (CP) infarct volumes after E2 replacement compared to oil treated WT females (*; p < .01). PARP-/- females demonstrated increased damage compared to WT (**; p < .01). Interestingly the neuroprotective effect of E2 was completely absent in PARP -/- females. E2 treatment exacerbated stroke damage; both striatal and total infarct volumes were significantly higher in E2 treated vs. oil treated PARP-/- mice (***; p < .05) [4].