Table 2.

Behavioral parameters of 6 and 12 month old PCAF KO and WT mice in the open-field test

Parameter	6-m.o. male mice		12-m.o. female mice
	WT	PCAF KO	WT	PCAF KO
Weight (g)	36.0 ± 0.6	35.5 ± 1.2	32.2 ± 0.9	36.3 ± 1.0
Latency to start (s)	1 ± 0	9 ± 2 *	0 ± 0	1 ± 0
Locomotion (m)	27.6 ± 2.4	35.8 ± 1.9	14.6 ± 2.2	20.3 ± 3.3
Loc. in center (%)	23.4 ± 1.9	31.1 ± 2.0	29.8 ± 4.2	17.4 ± 2.0 *
Speed (m/min)	3.29 ± 0.20	4.28 ± 0.19	2.60 ± 0.18	3.30 ± 0.33
Immobility (s)	98 ± 25	93 ± 7	285 ± 36	243 ± 31
Rearing	14 ± 2	52 ± 7 **	8 ± 3	20 ± 2 **
Grooming	5 ± 0	24 ± 2 **	5 ± 1	5 ± 1
Defecations	2 ± 0	3 ± 0	4 ± 1	6 ± 0
n	8	4	12	13

^*p < 0.05,

^**p < 0.01 vs. the age-matched WT group, Student’s t-test.