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. Author manuscript; available in PMC: 2009 Apr 15.
Published in final edited form as: Cancer Res. 2008 Apr 15;68(8):2652–2660. doi: 10.1158/0008-5472.CAN-07-5873

Figure 2. Histopathological and molecular analysis of lung neoplasms from RNR transgenic mice. (A).

Figure 2

(I) Lungs from a Rrm2Tg mouse with multiple independent neoplasms affecting several lobes. (II–VI) H&E-stained sections of lung neoplasms. (II) Solid adenoma from a p53R2Tg mouse. (III–VI) Papillary adenocarcinomas from Rrm2Tg or p53R2Tg mice showing pleural invasion (arrow) (III), regional variation in growth pattern (IV), multiple mitotic figures (arrows) (V), and blood vessel invasion (arrow) (VI). (VII, VIII) Immunohistochemical staining of RNR-induced lung neoplasms for Pro-SP-C (VII) or CC10 (VIII) by the ABC method, with methyl green counterstain. Inserts show higher magnification views of the boxed regions. Calibration bar: II, IV: 50 μm; III: 241 μm; V: 10 μm; VI: 25 μm; VII, VIII: 100 μm. (B) Northern blot analysis of lung neoplasms from RNR transgenic mice. Total RNA was prepared from lung neoplasms (Tumor 1, Tumor 2, Tumor 3) or normal lung tissue (Lung) from RNR transgenic mice, as well as from wild-type FVB lung tissue (WT FVB). Northern blotting was performed with the indicated radiolabeled probes.