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. Author manuscript; available in PMC: 2009 Apr 15.
Published in final edited form as: Cancer Res. 2008 Apr 15;68(8):2652–2660. doi: 10.1158/0008-5472.CAN-07-5873

Table 2.

Combining RNR overexpression with mismatch repair deficiency results in a synergistic increase in lung carcinogenesis

Mouse genotype # of animals % of mice with lung neoplasms % of mice with multiple lung neoplasms # of lung neoplasms per mouse† ± SD Average lung neoplasm size (mm) ± SD % of mice with lymphoma
Msh6−/−Rrm2Tg 13 100%* 69%* 2.9 ± 1.99 1.30 ± 0.54 31%
Msh6−/− 13 15% 0% 1.0 ± 0 1.25 ± 1.06 8%
Msh6+/−Rrm2Tg 17 18% 0% 1.0 ± 0 0.73 ± 0.68 12%
Msh6+/− 10 0% 0% N/A N/A 0%
Msh6+/+Rrm2Tg 18 17% 6% 1.33 ± 0.58 1.23 ± 0.25 0%
Msh6+/+ 14 0% 0% N/A N/A 0%

NOTE: Mice were aged for 6 months, euthanized by asphyxiation using carbon dioxide, and subjected to pathological examination as described in Materials and Methods. Only mice that lived to 6 months were included. Four Msh6−/−Rrm2Tg mice died before 6 months due to lymphoma, one of which also had a lung neoplasm. Four Msh6−/− mice died before 6 months due to lymphoma.

†

Values refer to the average number of lung neoplasms per mouse among tumor-bearing animals only.

*

Statistically significant difference (p<0.01) relative to Msh6−/−, Msh6+/−Rrm2Tg, or Msh6+/+Rrm2Tg mice as determined by Fisher’s Exact test.