Skip to main content
. Author manuscript; available in PMC: 2009 May 7.
Published in final edited form as: J Theor Biol. 2008 Jan 20;252(1):24–38. doi: 10.1016/j.jtbi.2008.01.010

Figure 1.

Figure 1

Simulated experimental scenarios for macrophage activation that depend on the timing of IFN-γ and TNF signaling relative to infection. “Infection Outcome” refers to the success or failure of macrophage responses, measured by the number of intracellular bacteria. In Scenario 1, TNF and IFN-γ signaling precedes infection. Scenario 2 represents targeted secretion of IFN-γ at the time of infection with TNF stimulation preceding. Scenario 3 represents TNF and IFN-γ signaling both concurrent with infection. The control scenario represents no cytokines present as is the case during an innate response. In this case the only activation signal is derived from mycobacteria during infection. After macrophages initially receive a given signal, we assume that signal is persistent.