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. Author manuscript; available in PMC: 2009 May 7.
Published in final edited form as: J Theor Biol. 2008 Jan 20;252(1):24–38. doi: 10.1016/j.jtbi.2008.01.010

Figure 3.

Figure 3

A. Cumulative nitrite output of J774.16 macrophages at 96 h after treatment with a wide range of ManLAM and IFN-γ doses. Note two distinct response phases based on the dose of IFN-γ marked 1 and 2. B. Simulated cumulative nitrite production at 96 h after treatment reproduces experimental trends. A version of the mathematical model without M. tuberculosis infection simulated the cell culture experiment. LOD: limit of detection for nitrite. The two asterisks denote dose levels excluded from the fitting (see Footnote 1 in the text).