. Author manuscript; available in PMC: 2009 May 7.

Published in final edited form as: J Theor Biol. 2008 Jan 20;252(1):24–38. doi: 10.1016/j.jtbi.2008.01.010

Table 1.

Macrophage regulatory interactions optimizing killing of M. tuberculosis and temporal responsiveness

	Transcriptional regulation of iNOS by:			Nitric oxide feedback to:
	NF-κB (g₃₁)	Stat1 (g₃₂)	LIP¹ (g₃₇)	NF-κB (g₁₆)	Stat1 (g₂₆)	IRP² (h₉₆)
Optimal Killing³	+	+	−	+	≈⁴	+
Optimal Response Time⁵	+	+	−	−	−	−

Regulation occurs indirectly via C/EBP-β in vivo.

IRP: Iron response protein. See Figure 2.

In all scenarios with cell-mediated immunity.

⁴

All Mtb numbers within 5% for positive (+), null (0) and negative (−) feedback.

⁵

Other criteria for macrophage function also conform to this result (Ray & Kirschner, 2006).