FIGURE 4.
The effect of hcTnI R145G mutation on maximal force (105 newtons/m2) and maximal ATPase activity (s-1/myosin head) in transgenic papillary muscle fibers, respectively. a, the maximal force was ∼14% lower in Tg-R145G fibers (n = 10) than in Tg-WT fibers (n = 14). b, there is no significant difference in maximal ATPase in Tg-R145G fibers (n = 9) compared with Tg-WT fibers (n = 13) (p > 0.05). There was no statistically significant difference in both maximal force and ATPase between NTg and Tg-WT fibers (p > 0.05). *, statistically significant difference (p < 0.05). Data are expressed as mean of n experiments ± S.E.