Table 2.
Associations of functional performance measures with total and cardiovascular mortality among participants with peripheral arterial disease after additional adjustment for physical activity levels*
| Baseline six-minute walk quartiles | Additional adjustment for blocks walked during the past week. | Additional adjustment for stair flights climbed during the past week | ||||
|---|---|---|---|---|---|---|
| Hazard Ratio (95% Confidence Interval) | p- value | p- trend | Hazard Ratio (95% Confidence Interval) | p- value | p- trend | |
| Total Mortality | ||||||
| 1st quartile (<897) | 2.40 (1.32 to 4.38) | 0.004 | 0.001 | 2.33 (1.31 to 4.16) | 0.004 | 0.001 |
| 2nd quartile
(<1158) |
1.57 (0.86 to 2.86) | 0.141 | 1.54 (0.86 to 2.76) | 0.149 | ||
| 3rd quartile
(<1400) |
0.98 (0.53 to 1.81) | 0.951 | 0.97 (0.53 to 1.76) | 0.912 | ||
| 4th quartile
(1400+) |
1.0 (Referent) | NA | 1.0 (Referent) | NA | ||
| Cardiovascular Mortality | ||||||
| 1st quartile (<897) | 5.36 (1.95 to 14.8) | 0.001 | <0.001 | 5.30 (1.79 to 15.7) | 0.003 | <0.001 |
| 2nd quartile
(<1158) |
3.80 (1.40 to 10.3) | 0.009 | 3.82 (1.35 to 10.8) | 0.012 | ||
| 3rd quartile
(<1400) |
1.60 (0.58 to 4.45) | 0.363 | 1.62 (0.57 to 4.60) | 0.369 | ||
| 4th quartile
(1400+) |
1.0 (Referent) | NA | 1.0 (Referent) | NA | ||
| Normal paced four-meter walking velocity | Additional adjustment for blocks walked during the past week. | Additional adjustment for stair flights climbed during the past week. | ||||
| Hazard Ratio (95% Confidence Interval) | p- value | p- trend | Hazard Ratio (95% Confidence Interval) | p- value | p- trend | |
| Total Mortality | ||||||
| 1st quartile (<0.759) | 1.85 (1.04 to 3.29) | 0.037 | 0.025 | 1.87 (1.06 to 3.30) | 0.031 | 0.022 |
| 2nd quartile
(<0.879) |
1.72 (0.99 to 2.97) | 0.054 | 1.73 (1.001 to 2.98) | 0.0497 | ||
| 3rd quartile
(<1.010) |
1.29 (0.72 to 2.32) | 0.400 | 1.32 (0.73 to 2.39) | 0.356 | ||
| 4th quartile
(1.010+) |
1.00 (Referent) | NA | 1.00 (Referent) | NA | ||
| Cardiovascular Mortality | ||||||
| 1st quartile (<0.759) | 2.33 (0.91 to 5.97) | 0.078 | 0.146 | 2.59 (1.04 to 6.44) | 0.041 | 0.139 |
| 2nd quartile
(<0.879) |
2.22 (0.96 to 5.15) | 0.063 | 2.35 (1.01 to 5.44) | 0.046 | ||
| 3rd quartile
(<1.010) |
2.09 (0.91 to 4.80) | 0.081 | 2.33 (1.01 to 5.36) | 0.047 | ||
| 4th quartile
(1.010+) |
1.0 (Referent) | NA | 1.0 (Referent) | NA | ||
| Fast-Paced Four Meter Walking Velocity | Additional adjustment for blocks walked during the past week. | Additional adjustment for stair flights climbed during the past week. | ||||
| Hazard Ratio (95% Confidence Interval) | p- value | p-trend | Hazard Ratio (95% Confidence Interval) | p-value | p-trend | |
| Total Mortality | ||||||
| 1st quartile (<1.034) | 1.88 (1.03 to 3.43) | 0.041 | 0.035 | 1.89 (1.04 to 3.44) | 0.036 | 0.032 |
| 2nd quartile
(<1.223) |
1.82 (1.04 to 3.17) | 0.036 | 1.82 (1.05 to 3.17) | 0.034 | ||
| 3rd quartile
(<1.379) |
1.50 (0.84 to 2.68) | 0.176 | 1.53 (0.85 to 2.74) | 0.156 | ||
| 4th quartile
(1.379+) |
1.0 (Referent) | NA | 1.0 (Referent) | NA | ||
| Cardiovascular Mortality | ||||||
| 1st quartile (<1.034) | 2.29 (0.84 to 6.25) | 0.106 | 0.087 | 2.54 (0.94 to 6.89) | 0.067 | 0.071 |
| 2nd quartile
(<1.223) |
2.40 (0.97 to 5.94) | 0.057 | 2.50 (1.01 to 6.14) | 0.047 | ||
| 3rd quartile
(<1.379) |
1.37 (0.48 to 3.92) | 0.554 | 1.49 (0.51 to 4.36) | 0.470 | ||
| 4th quartile
(1.379+) |
1.0 (Referent) | NA | 1.0 (Referent) | NA | ||
*
Hazard ratios are shown with (95% confidence intervals). Analyses adjust for age, sex, race, comorbidities, cigarette smoking, body mass index, and the ankle brachial index in addition to the physical activity measures listed at the top of each column.