Figure 1. Characterization of E2’s effects on hippocampuse-mediated processes.
Figure depicts that rats that have proestrus-like, physiological levels of E2 in the hippocampus (proestrous, OVX + E2 subcutaneously (SC) or to the hippocampus (hippo); levels + sem indicated by circles) have improved performance in the elevated plus maze compared to diestrous or OVX rats (behavior indicated by bars; mean secs + sem). * indicates significant difference from diestrous or OVX, vehicle control.