Figure 3.

Schematic representation of the MAO-dependent pathway for suppression of mitochondrial electron flow and subsequent recovery. MAO activity (outer membrane) leads to formation of GSSG, which forms disulfide linkages (Pr-SSG) with cysteine resides of proteins associated with the inner membrane, resulting in suppression of electron transport. The inhibition is relieved by reduction of GSSG by GSSG reductase, leading to reversal of the reaction that forms Pr-SSG. The NADPH-dependent protein-disulfide reductase activity of thioredoxin may also participate.