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Alternative metabolism of the cholesterol-derived steroids pregnenolone and DHEA to either Cyp7b products or 3β-hydroxysteroid dehydrogenase (3β-HSD) products progesterone and androstenedione (that are not effective substrates for Cyp7b; Table 1). ∗, It is so far unknown whether Cyp17 (steroid 17-hydroxylase/17,20 lyase) catalyzes the conversion of 7HP to 7HD. Cyp11a1, side-chain cleavage enzyme (scc); 7HD, 7α-hydroxy DHEA; 7HP, 7α-hydroxy pregnenolone.
