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The RBD of RIN1 interferes with RAS signaling. NIH 3T3 cells were transfected with PGS2-luciferase with or without v-src. 3 μg or 6 μg of pcDNA3HA–RIN1C (RIN1C) and 3 μg H-RASN17 (DNRas) were used as indicated. pcDNA3HA was the control vector. The data represent experiments performed in triplicate. Multiple experiments were performed with the same result in each case.
