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. 1973 Aug;115(2):682–690. doi: 10.1128/jb.115.2.682-690.1973

Studies on the Developmental Cycle of Chlamydia trachomatis: Selective Inhibition by Hydroxyurea

Herbert S Rosenkranz 1, Bezalel Gutter 1, Yechiel Becker 1
PMCID: PMC246300  PMID: 4725618

Abstract

Hydroxyurea, a potent inhibitor of deoxyribonucleic acid synthesis, inhibits the development of trachoma agent when applied at a concentration of 5 × 10−2 M. At a lower concentration, 5 × 10−4 M, hydroxyurea permits the development of the trachoma inclusion bodies and initial bodies, but arrests the formation of elementary bodies, the infectious entity of the agent. The inhibitory effect of 5 × 10−4 M hydroxyurea is reversible and can be used to synchronize the development of the agent. The synthesis of deoxyribonucleic acid, ribonucleic acid, and proteins takes place in the initial bodies after the removal of the inhibitor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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