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. Author manuscript; available in PMC: 2009 May 1.
Published in final edited form as: J Oral Maxillofac Surg. 2008 May;66(5):987–994. doi: 10.1016/j.joms.2008.01.038

Figure 2.

Figure 2

Figure 2

Matrix necrosis in the mandible of dogs treated for 3 years with alendronate. The second molar region was stained en bloc with basic fuchsin with regions of matrix necrosis defined as those regions void of stain uptake. Necrotic bone matrix can be observed using brightfield microscopy (A, D, E). Due to its fluorescent properties, stained regions can be visualized using confocal microscopy, revealing patent canalicular networks (B,G). Conversely, necrotic regions which are void of stain can are without patent canalicular networks (C, F, H).