Table 2.

Intracortical bone turnover of the mandible

	Vehicle 1 ml/kg/day	Alendronate 0.2 mg/kg/day	Alendronate 1.0 mg/kg/day	Pooled Alendronate doses
N	12	12	12	24
Alveolar bone
Bone area, mm2	15.6 ± 1.7	13.3 ± 1.1	17.4 ± 2.3	15.2 ± 1.3
Labeled osteons, #/mm2	0.52 ± 0.18	0.25 ± 0.12	0.13 ± 0.10	0.20 ± 0.08
MAR, um/day	1.37 ± 0.25	0.56 ± 0.25 a	0.39 ± 0.28 a	0.37 ± 0.15 a
Non-alveolar bone
Bone area, mm2	43.1 ± 2.7	48.0 ± 3.1	50.1 ± 3.3	49.0 ± 2.2
Labeled osteons, #/mm2	0.062 ± 0.02	0.038 ± 0.01	0.004 ± 0.002 a	0.02 ± 0.01 a
MAR, um/day	0.80 ± 0.25	0.72 ± 0.23	0.21 ± 0.14	0.50 ± 0.15
Overall mandible
Bone area, mm2	58.6 ± 3.5	61.3 ± 3.2	67.4 ± 2.9	64.2 ± 2.2
Labeled osteons, #/mm2	0.18 ± 0.04	0.09 ± 0.03 a	0.03 ± 0.02 a	0.06 ± 0.02 a

Data (mean ± SE) represent one tissue section per animal.

^ap < 0.05 versus vehicle.