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. 2008 Mar 27;586(Pt 10):2523–2538. doi: 10.1113/jphysiol.2007.148197

Figure 6. Blockade of calcium influx with cadmium has comparable effects as block of SK channels with apamin.

Figure 6

Aa, application of 100 μm cadmium after concurrent application of Cgtx MVIIC and GVIA both at 3 μm further increased the firing rate and reduced the duration of the bursts. Sample raw data are also shown. Ab, histogram of the interspike interval of the cell in Aa. B, average and individual data obtained after sequentially adding: a mixture of blockers of L-, N-, P/Q- and R/T-type calcium channels (2 μm nimodipine, 1 μm Cgtx GVIA, 200 nm ω-agatoxin and 5 μm mibefradil), then 500 nm SNX-482 (to block R-type calcium channels), then 50 μm nickel and finally 100 μm cadmium. *P < 0.05, **P < 0.001, n = 9 cells. C, average and individual data showing the duration of the bursts for the same cells presented in Fig. 6B. *P < 0.05. D, average and individual firing rates in cells first exposed to 100 nm apamin and then to 100 μm cadmium. E, average and individual firing rates in cells first exposed to 100 μm cadmium and then to 100 nm apamin. F, average and individual data showing the duration of the bursts for the same cells presented in D and E. n.s., not significant.