Table 2 Changes in coagulation parameters in normal volunteers infused with 1000 ml of 0.9% saline or Gelofusine.
| Change from control | ||
|---|---|---|
| Saline | Gelofusine | |
| INR | 0.01 (−0.02 to 0.04) | 0.04 (−0.01 to 0.09) |
| APTT | −0.54 (−1.8 to 0.73) | 0.17 (−1.42 to 1.75) |
| TT | −0.03 (−0.71 to 0.65) | 0.41 (−0.26 to 1.75) |
| D‐dimer (ng/ml) | 0.6 (−2.0 to 3.2) | 1.8 (−3.3 to 6.9) |
| Tissue factor ag (pg/ml) | −0.3 (−10.8 to 10.3) | 15 (−16.8 to 46.8) |
| Antithrombin III (IU/ml) | −1.1 (−7.2 to 5.0) | −1.1 (−12.4 to 10.2) |
| vWF ag (%) | −0.5 (−1.6 to 0.7) | 3.3 (−4.3 to 10.8) |
| Fibrinogen (mg/dl) | −11.5 (−28.8 to 5.7) | −9.1 (−46.5 to 28.3) |
ACT, activated clotting time; ag, antigen; APTT, activated partial thromboplastin time; INR, international normalised ratio; TT, thromboplastin time; vWF ag; von‐Willebrand factor antigen.