Table 3. Demographic and clinical features of control subjects and primary open angle glaucoma patients with or without TT/GG compound genotype of rs1048661 and rs3825942 in LOXL1.
|
Control |
POAG |
|||||
|
Feature |
TT/GG compound genotype |
TT/GG compound genotype |
||||
|
+ (n=59) |
- (n=132) |
p value* |
+ (n=59) |
- (n=154) |
p value* |
|
|
Age at blood sampling (years) |
64.0 ± 12.2 |
66.5 ± 11.0 |
0.16 |
63.2±14.9 |
62.8±14.8 |
0.88 |
|
Age at diagnosis (years) |
- |
- |
- |
56.3±15.4 |
53.7±15.2 |
0.28 |
|
Male gender, n (%) |
22 (37.3) |
48 (36.4) |
>0.99 |
40 (67.8) |
89 (57.8) |
0.21 |
|
Familial history of glaucoma, n (%) |
0 (0) |
0 (0) |
1 |
15 (25.4) |
47 (30.5) |
0.5 |
|
Refractive error (diopter) |
−0.45±2.2 |
−0.31±2.1 |
0.67 |
−2.2±3.2 |
−2.1±2.9 |
0.84 |
|
Maximum IOP (mmHg) |
15.2 ± 2.6 |
14.9±2.8 |
0.55 |
27.4±6.0 |
28.9±9.9 |
0.27 |
|
History of laser trabeculoplasty, n (%) |
- |
- |
- |
10 (16.9) |
26 (16.9) |
>0.99 |
| History of glaucoma surgery, n (%) | - | - | - | 18 (30.5) | 48 (31.2) | >0.99 |
No significant differences were noted in the demographic and clinical features of POAG patients as well as control subjects with and without the TT/GG compound genotype. Continuous variables are expressed as means±standard deviation. The asterisk indicates that the Student t-test or the Fisher's exact test was done. LOXL1: lysyl oxidase-like 1, POAG: primary open angle glaucoma, IOP: intraocular pressure.