Figure 2.
Adult neurogenesis in the dentate gyrus of the hippocampus. Summary of the current knowledge on the development of neural stem cells during adult hippocampal neurogenesis in young adult mice as characterized by estimated timeline, developmental stages, expression of specific markers, physiological properties, critical periods and potential molecular mechanisms. ML: molecular layer; GCL: granule cell layer; SGZ: subgranular zone; GFAP: gial fibrillary acidic protein; BLBP: brain lipid-binding protein; DCX: doublecortin; NeuN: neuronal nuclei; PSA-NCAM: the polysialylated form of the neural cell adhesion molecule NCAM; POMC: pro-opiomelanocortin; IEG: immediate early gene; LTP: long-term potentiation; TXL: tailless; EGF: epidermal growth factor; FGF: fibroblast growth factor; VEGF: vascular endothelial growth factor; BMP: bone morphogenetic protein; GABA: γ-aminobutyric acid; DISC1: disrupted-in-schizophrenia 1.
