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. Author manuscript; available in PMC: 2009 Apr 8.
Published in final edited form as: Vaccine. 2008 Feb 20;26(16):2020–2033. doi: 10.1016/j.vaccine.2008.02.009

Table 7.

Effect of vaccines on IC c hallenge with WNV in CD8−/− mice

Vaccination Challenge Dose WNV PFU # survived/total P value
Challenge: Day 60, no boost
Placebo 101 0/10
DNA plasmid 101 1/10 0.2
Inactivated WNV 101 4/10 < 0.001
Challenge: Day 70, one boost
Placebo 101 0/10
DNA plasmid 101 4/10 0.005
Inactivated WNV 101 8/10 < 0.0005

CD8−/− mice were vaccinated DNA plasmid, formalin-inactivated WNV New York, and placebo vaccines. Mice were challenge after primary immunization at day 60 or ten days after a boost, at day 70 with either 101 PFU of WNV by an IC route and monitored for survival for 28 days. P values were determined using the log rank test.