Table 1.
Murine ischemia reperfusion cardiomyopathy (I/RC): Summary of previous and current results
| Variable | Wild-type sham (4–6) | Wild-type I/RC (4–6) | Wild-type I/RC + SAP (6) | FcRγ−/− sham | FcRγ−/− I/RC | FcRγ−/− I/RC + SAP | |
|---|---|---|---|---|---|---|---|
| Histology | Collagen | — | +++ | + | — | +++ | ++++ |
| Myofibroblasts | — | +++ | — | — | +++ | +++ | |
| Macrophages | — | +++ | +++ | — | ++ | ++ | |
| Isolated cells | CD34+ | — | +++ | — | — | +++ | +++ |
| CD45+ | — | +++ | ++ | — | ++++ | ++++ | |
| CD34+/CD45+ | — | +++ | — | — | ++ | ++ | |
| Proliferation | — | +++ | — | — | +++ | +++ | |
| Morphology | big, flat | small, spindle | big, flat | big, flat | small, spindle | small, spindle | |
| Function | % Fractional shortening | — | −−− | — | — | −−− | −−− |
| % Anterior wall thickening | — | −−− | — | — | −−− | −−− |
For better comparison, data from previously published studies (4–6) and the current study, which is a direct extension of the earlier ones, are summarized. Data are represented by symbols: —, baseline levels; +, activated levels; the amount of + is proportional to the extent of increase (histology and cell markers). Reduced function is measured by the number of −. Despite identical genetic background (C57BL/6), minor differences in absolute values between wild-type and FcRγ −/− mice existed, but these were independent of the presence or absence of SAP during I/RC.