Table 2.
Regions associated with clefting susceptibility
| Teratogen location* | Phenytoin
|
6-AN
|
Either P value | ||||
|---|---|---|---|---|---|---|---|
| A/B† | χ2 | P value | A/B† | χ2 | P value | ||
| 1 (9) | B | 26.2 | 0.078 | A | 58.6 | 0.1016 | 0.046 |
| 3 (54–64) | A | 35.0 | 0.023 | B | 52.8 | 0.1484 | 0.023 |
| 4 (36–45) | A | 35.5 | 0.019 | B | 82.3 | 0.0430 | 0.007 |
| 4 (55) | A | 8.8 | 0.176 | B | 82.3 | 0.0430 | 0.044 |
| 5 (28–34) | B | 79.8 | 0.004 | B | 43.7 | 0.1484 | 0.005 |
| 5 (66) | A | 17.1 | 0.125 | B | 94.9 | 0.0078 | 0.008 |
| 7 (43) | A | 53.4 | 0.031 | B | 71.4 | 0.0313 | 0.008 |
| 8 (15–31) | B | 21.2 | 0.047 | A | 78.0 | 0.0488 | 0.016 |
| 9 (27–39) | B | 5.0 | 0.316 | B | 96.5 | 0.0234 | 0.044 |
| 11 (16–33) | A | 5.2 | 0.297 | A | 105.7 | 0.0313 | 0.053 |
| 12 (3–15) | B | 62.6 | 0.008 | A | 72.9 | 0.0605 | 0.004 |
| 12 (52–60) | B | 62.6 | 0.008 | A | 5.6 | 0.7300 | 0.035 |
| 14 (9) | A | 3.1 | 0.445 | B | 73.5 | 0.0469 | 0.102 |
| 15 (57–59) | B | 26.1 | 0.062 | A | 96.1 | 0.0469 | 0.013 |
| 17 (1) | A | 4.0 | 0.359 | B | 124.1 | 0.0117 | 0.027 |
| 19 (6–22) | A | 24.7 | 0.031 | B | 39.9 | 0.3125 | 0.055 |
*
Chromosome (map distance in cM from centromere).
†
Clefting higher with A = A/J, or B = C57BL/6J allele.